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Last steps in escort aptamer thinking encompass man-made adjustment of truncated aptamer

Last steps in escort aptamer thinking encompass man-made adjustment of truncated aptamer Further nuclease stabilization is achieved by substitution of 2?-OCH3 for 2?-OH at purine positions. As the 2?-OCH3 moiety is not compatible with current SELEX process enzymes, this alteration must occur during chemical synthesis following evolution of a specific aptamer sequence. Generally, most of...